SYSTEMIC LUPUS ERYTHEMATOSIS (SLE)

definisi : autoimmune bercirikan inflamasi kronik dan melibatkan connective tissue

etiologi :

-genetik

-hormon estrogen

-infeksi

-ubatan

-sinar UV

mk :

-butterfly rash

-discoid leision

-ulcer mulut

-alopecia

-demam

-letih lesu

-photosensitive

-ruam

-arthritis

-anorexia, nausea

-sakit abdomen

-diarrhea

-pembesaran liver

-gangguan fungsi liver

-CVS : pericarditis, vasculitis, myocarditis, venous thrombosis

-paru2 : pleurisy, pleural effusion, pneumonia

-renal : deposit protein, renal calculi, edema, proteinuria, hypertension, renal failure

-haemolytic anaemia

-conjunctivitis, photophobia

ujian :

-HbTWDC

-positive ANA

-renal biopsy

-BUSE, serum creatinine

-serum albumin

-serum immune complex assay

-skin biopsy